Protein Details: Glutamate receptor ionotropic;NMDA 2A

Protein ID

ICDB_Pro_0817

Protein Name

Glutamate receptor ionotropic;NMDA 2A

Gene Name

GRIN2A; NMDAR2A

Organism

Homo sapiens (Human)

Length

1464 amino acids

AlphaFoldDB

AF-Q12879-F1-model_v4.pdb

Function

Component of NMDA receptor complexes that function as heterotetrameric;ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit;glycine binding to the zeta subunit;plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B. Contributes to the slow phase of excitatory postsynaptic current;long-term synaptic potentiation;and learning (By similarity). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1;into the synaptic cleft;upon F2R/PAR-1 activation in astrocyte (By similarity).

Sequence

MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNPATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNRRVYKKMPSIESDV

PDB Structures

3NFL 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 8E99

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 44; /ligand="Zn(2+)"; BINDING 128; /ligand="Zn(2+)"; BINDING 266; /ligand="Zn(2+)"; BINDING 282; /ligand="Zn(2+)"; BINDING 511..513; /ligand="L-glutamate"; BINDING 518; /ligand="L-glutamate"; BINDING 689..690; /ligand="L-glutamate"; BINDING 730..731; /ligand="L-glutamate"

Disease

Epilepsy;Focal;With Speech Disorder And With Or Without Impaired Intellectual Development and Landau-Kleffner Syndrome

Location

DOI ID

10.1016/0167-4889(94)90086-8; 10.1038/nature03187; 10.1101/gr.2596504; 10.1021/acs.jmedchem.5b02010; 10.1016/j.neuron.2016.01.016; 10.1021/acsmedchemlett.6b00388; 10.1038/ng.677; 10.1038/ng.810; 10.1038/tp.2011.52; 10.1056/nejmoa1206524; 10.1038/ng.2726; 10.1038/ng.2728; 10.1038/ng.2727; 10.3389/fonc.2013.00333; 10.1111/epi.12663; 10.1038/ncomms4251; 10.1016/j.neuron.2015.11.009; 10.1016/j.ajhg.2016.10.002; 10.1002/humu.23149; 10.1124/mol.116.106781; 10.1371/journal.pone.0170818; 10.1371/journal.pgen.1006536

RefSeq

NP_000824.1 [Q12879-1]; NP_001127879.1 [Q12879-1]; NP_001127880.1 [Q12879-2]; XP_011520763.1